HMI stands for Human-Machine-Interface. In short, it refers to the interface between the user and the vehicle, which requires special attention in the TWIKE 5 due to the integrated pedal system, but also offers unique opportunities. This is because the pedal system and the ergonomic seating posture adapted to it with pronounced lordosis support enable extremely healthy sitting and, incidentally, fitness maintenance movement on everyday journeys. The pilot's feet are always in contact with the pedals, which control the hydraulic brake when pedalling back. The time it takes to change from the accelerator pedal to the brake pedal cannot be shorter, there is simply none.

The round instrument located in the driver's direct line of vision for displaying all legally prescribed driving information, such as speed, high beam or indicator light, is never obscured by the spoke of a steering wheel. This also simply does not exist. Instead, the TWIKE is controlled intuitively with 2 mechanically coupled hand levers, the arm muscles know the motion sequence from the familiar steering wheel. The round instrument rests safely shaded under a dashboard, the most important operating keys are located near this instrument.

Additional instruments such as a smartphone or pad (so-called bring-in-devices) can be easily attached to the middle section of the dashboard with standard holders or to the roll bar above the head of the central bar. Overall, the HMI concept of the TWIKE 5 is as reduced as possible, but gives the opportunity to combine individual and up-to-date devices for additional functions (navigation, multimedia, camera, ...). For everyday requirements (charging status, speed, high beam, indicator light,...), however, the basic equipment is already sufficient.